Version: 8.0.0
Date: Tue Jan 28 2025
Tpm2
Mus musculusMGI:98810
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tpm2

Species
Mus musculus
Symbol
Tpm2
Name
tropomyosin 2, beta
Synonyms
  • Tpm-2
  • Trop-2
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Predicted to be located in actin cytoskeleton. Predicted to be part of muscle thin filament tropomyosin. Predicted to be active in actin filament. Is expressed in several structures, including cochlea; lateral plate mesoderm; musculature; retina; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2).
MGI Description
PHENOTYPE: Homozygous mice for a null allele exhibit embryonic lethality. Heterozygotes develop cataracts and show impaired healing of lens wounds. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19269
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tpm2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Tpm2 role
            Tpm2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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