Gene

Tpm2

Species
Mus musculus
Symbol
Tpm2
Name
tropomyosin 2, beta
Synonyms
  • Tpm-2
  • Trop-2
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Predicted to be located in actin cytoskeleton. Predicted to be part of muscle thin filament tropomyosin. Predicted to be active in actin filament. Is expressed in several structures, including cochlea; lateral plate mesoderm; musculature; retina; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2).
MGI Description
PHENOTYPE: Homozygous mice for a null allele exhibit embryonic lethality. Heterozygotes develop cataracts and show impaired healing of lens wounds. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19269
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            43.515M43.516M43.517M43.518M43.519M43.520M43.521M43.522M43.523M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Tpm2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Tpm2 role
              Tpm2 genetic perturbation
              Interactor gene
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