Version: 8.0.0
Date: Tue Jan 28 2025
Hsp90b1
Mus musculusMGI:98817
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hsp90b1

Species
Mus musculus
Symbol
Hsp90b1
Name
heat shock protein 90, beta (Grp94), member 1
Synonyms
  • 90 kDa
  • endoplasmin
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).
MGI Description
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11528
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hsp90b1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Hsp90b1 role
            Hsp90b1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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