Version: 8.0.0
Date: Tue Jan 28 2025
Tshr
Mus musculusMGI:98849
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tshr

Species
Mus musculus
Symbol
Tshr
Name
thyroid stimulating hormone receptor
Synonyms
  • AI481368
  • expressed sequence AI481368
Biotype
protein coding gene
Automated Description
Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in endocrine gland and urinary system. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); cardiomyopathy; hyperthyroidism (multiple); and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor).
MGI Description
PHENOTYPE: Mutations in this gene exhibit profound hypothyroidism, developmental and growth retardation, impaired hearing with cochlear defects, and infertility. One mutation results in high postweaning mortality. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24372
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tshr molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Tshr role
            Tshr genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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