Gene

Usp4

Species
Mus musculus
Symbol
Usp4
Name
ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms
  • F730026I20Rik
  • RIKEN cDNA F730026I20 gene
Biotype
protein coding gene
Automated Description
Predicted to enable adenosine receptor binding activity; cysteine-type deubiquitinase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of TORC1 signaling; protein localization to cell surface; and spliceosomal tri-snRNP complex assembly. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Is expressed in facial prominence ectoderm and facial prominence mesenchyme. Orthologous to human USP4 (ubiquitin specific peptidase 4).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased irradiation-induced apoptosis, slow cellular growth, resistance to oncogenic transformation, and early cellular replicative senescence. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21646
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Usp4 molecule type
          Interactor gene
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            Genetic Interactions

            Usp4 role
            Usp4 genetic perturbation
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