Gene

Vldlr

Species
Mus musculus
Symbol
Vldlr
Name
very low density lipoprotein receptor
Synonyms
  • AA408956
  • AI451093
Biotype
protein coding gene
Automated Description
Enables reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of dendrite development; and reelin-mediated signaling pathway. Acts upstream of or within positive regulation of protein kinase activity. Located in extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study age related macular degeneration 1. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
MGI Description
PHENOTYPE: Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation. Abnormal retinal vascularization is also found. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24270
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
27.195M27.200M27.205M27.210M27.215M27.220M27.225M27.230M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions