Gene

Xist

Species
Mus musculus
Symbol
Xist
Name
inactive X specific transcripts
Synonyms
  • AI314753
  • expressed sequence AI314753
Biotype
lncRNA gene
Automated Description
Enables ribonucleoprotein complex binding activity. Acts upstream of or within inactivation of paternal X chromosome by genomic imprinting; random inactivation of X chromosome; and spongiotrophoblast differentiation. Located in X chromosome and nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; neural retina; and spleen. Orthologous to human XIST (X inactive specific transcript).
MGI Description
PHENOTYPE: Xist function in X-inactivation is disrupted in females carrying a null mutation. Depending on maternal or paternal derivation of the mutation, females survive or die in early embryogenesis. In either case, X-inactivation is non-random and abnormal. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            102.504M102.506M102.508M102.510M102.512M102.514M102.516M102.518M102.520M102.522M102.524M102.526M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Xist molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Xist role
              Xist genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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