Gene

Zfp57

Species
Mus musculus
Symbol
Zfp57
Name
zinc finger protein 57
Synonyms
  • G19
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within epigenetic programming in the zygotic pronuclei; genomic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23232
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Zfp933147439262 of 9 
Zfp777255534212 of 9 
Gm45871347636252 of 9 
Gm14325443738253 of 9 
Zfp398557828192 of 9 
Gm4724647236232 of 9 
Zfp965647236232 of 9 
Gm14322736942283 of 9 
Gm2007846536222 of 9 
Gm2026846536222 of 9 
Gm4631846536222 of 9 
Gm14308846536222 of 9 
Gm14434846536222 of 9 
Gm14391945136232 of 9 
Zfp9671039439262 of 9 
Zfp9661039439262 of 9 
Zfp9681039439262 of 9 
Zfp955b1140737262 of 9 
2010315B03Rik1239140252 of 9 
Zfp9711336739253 of 9 
AI9879441440237242 of 9 
Zfp5581540934242 of 9 
Zfp9311632343282 of 9 
Zfp8251731842282 of 9 
Zbtb411836734242 of 9 
Zfp7681932640262 of 9 
Zfp3192028838252 of 9 
Gm14418212 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Showing 1 - 4 of 4 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
37.308M37.310M37.312M37.314M37.316M37.318M37.320M37.322M37.324M37.326M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Zfp57tm1a(EUCOMM)Hmguallele
Zfp57tm1Xjliallele
Yes
Zfp57tm1.1Xjliallele
Yes
Zfp57tm1(KOMP)Wtsiallele
NC_000083.7:g.37310930C>Gvariant
SNP
  • 5 prime UTR variant
NC_000083.7:g.37311432C>Tvariant
SNP
  • 5 prime UTR variant
NC_000083.7:g.37312258T>Avariant
SNP
  • intron variant
NC_000083.7:g.37312422A>Gvariant
SNP
  • intron variant
NC_000083.7:g.37307663A>Gvariant
SNP
  • non coding transcript exon variant
NC_000083.7:g.37307764C>Tvariant
SNP
  • non coding transcript exon variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Tg(Zp3-cre)93Knw/0 Zfp57tm1Xjli/Zfp57tm1Xjli [background:] either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)
  • lethality throughout fetal growth and development, incomplete penetrance
  • maternal effect
MGI
Zfp57tm1.1Xjli/Zfp57tm1.1Xjli [background:] either: 129S6/SvEvTac-Zfp57tm1.1Xjli or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)
  • abnormal imprinting
  • lethality throughout fetal growth and development, incomplete penetrance
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
37.313M37.314M37.315M37.316M37.317M37.318M37.319M37.320M37.321MENSMUST00000069250 (Zfp57)ENSMUST00000089968 (Zfp57)ENSMUST00000172527 (Zfp57)ENSMUST00000172540 (Zfp57)ENSMUST00000172580 (Zfp57)ENSMUST00000173588 (Zfp57)ENSMUST00000173921 (Zfp57)ENSMUST00000174524 (Zfp57)ENSMUST00000174672 (Zfp57)ENSMUST00000174747 (Zfp57)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

9 interactor genes based on 9 annotations
Zfp57 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Dnmt1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Dnmt3aMus musculus
protein
  • biochemical
PMID:32325033
protein
Usp7Mus musculus
protein
  • affinity chromatography technology
PMID:37196079
protein
Zfp92Mus musculus
protein
  • biochemical
PMID:32325033
protein
Zfp93Mus musculus
protein
  • biochemical
PMID:32325033
protein
Zfp128Mus musculus
protein
  • biochemical
PMID:32325033
protein
Zfp287Mus musculus
protein
  • biochemical
PMID:32325033
protein
Zfp568Mus musculus
protein
  • biochemical
PMID:32325033
protein
Zfp667Mus musculus
protein
  • biochemical
PMID:32325033
Showing 1 - 9 of 9 rows
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Genetic Interactions

No data available