Gene

Zp2

Species
Mus musculus
Symbol
Zp2
Name
zona pellucida glycoprotein 2
Synonyms
  • Zp-2
Biotype
protein coding gene
Automated Description
Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Located in several cellular components, including collagen-containing extracellular matrix; endoplasmic reticulum; and multivesicular body. Is expressed in germ cell of ovary; oocyte; ovary; secondary oocyte; and testis. Orthologous to human ZP2 (zona pellucida glycoprotein 2).
MGI Description
PHENOTYPE: Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23343
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensZP29 of 10YesYes  
Rattus norvegicusZp28 of 9YesYes   
Xenopus tropicaliszp28 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Zp1156044283 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cumulus oophorus morphology
decreased superovulation rate
decreased tertiary ovarian follicle number
female infertility
thin zona pellucida
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(Zp2*)#Dean
Mus musculusTg(Zp2*)3Dean
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Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Tg(ZP2)2Dean/0 Tg(ZP3)7812Dean/? Zp2tm1Dean/Zp2tm1Dean Zp3tm1Dean/Zp3tm1Dean [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N
  • abnormal embryo development
  • decreased litter size
MGI
Tg(ZP2)2Dean/0 Zp2tm1Dean/Zp2tm1Dean [background:] involves: 129S1/Sv * 129X1/SvJ * CF-1 * FVB/N
  • abnormal embryo development
  • decreased litter size
MGI
Zp2tm1Dean/Zp2tm1Dean [background:] involves: 129S1/Sv * 129X1/SvJ * CF-1
  • abnormal cumulus oophorus morphology
  • decreased superovulation rate
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
119.726M119.728M119.730M119.732M119.734M119.736M119.738M119.740M119.742M119.744MENSMUST00000033207 (Zp2)ENSMUST00000207333 (Zp2)ENSMUST00000207726 (Zp2)ENSMUST00000208874 (Zp2)NM_001374631.1 (Zp2)NM_011775.7 (Zp2)XM_006507590.4 (Zp2)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Zp2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
AcrMus musculus
protein
  • unspecified method
PMID:11739644
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Genetic Interactions

No data available