Version: 8.1.0
Date: Fri Apr 18 2025
Hyal1
Rattus norvegicusRGD:1303060
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hyal1

Species
Rattus norvegicus
Symbol
Hyal1
Name
hyaluronidase 1
Synonyms
  • hyal-1
  • hyaluronidase-1
Biotype
protein coding gene
Automated Description
Predicted to enable chondroitin hydrolase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; glycosaminoglycan catabolic process; and regulation of cell growth. Predicted to act upstream of or within embryonic skeletal joint morphogenesis. Predicted to be located in extracellular space; hyaluranon cable; and lysosome. Predicted to be active in cytoplasmic vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1).
RGD Description
Predicted to enable chondroitin hydrolase activity and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; glycosaminoglycan catabolic process; and regulation of cell growth. Predicted to act upstream of or within embryonic skeletal joint morphogenesis. Predicted to be located in extracellular space; hyaluranon cable; and lysosome. Predicted to be active in cytoplasmic vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11769
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hyal1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Hyal1 role
            Hyal1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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