Species

Rattus norvegicus

Symbol

Tyrobp

Name

transmembrane immune signaling adaptor Tyrobp

Synonyms

DAP12
DNAX-activation protein 12

Biotype

protein coding gene

Automated Description

Predicted to enable protein homodimerization activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of cytokine production. Predicted to act upstream of or within osteoclast differentiation and regulation of osteoclast development. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP).

RGD Description

Predicted to enable protein homodimerization activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of cytokine production. Predicted to act upstream of or within osteoclast differentiation and regulation of osteoclast development. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR17554

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

No data available

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr1:85672931...85676856 + (3.93 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Tyrobp molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Tyrobp role	Tyrobp genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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