Gene

Bace2

Species
Rattus norvegicus
Symbol
Bace2
Name
beta-secretase 2
Synonyms
  • beta-site amyloid precursor protein cleaving enzyme 2
  • beta-site APP cleaving enzyme 2
Biotype
protein coding gene
Automated Description
Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2).
RGD Description
Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47965
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
36.71M36.72M36.73M36.74M36.75M36.76M36.77M36.78M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions