Gene

Brd2

Species
Rattus norvegicus
Symbol
Brd2
Name
bromodomain containing 2
Synonyms
  • bromodomain-containing 2
  • bromodomain-containing protein 2
Biotype
protein coding gene
Automated Description
Predicted to enable chromatin binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin looping; nucleosome assembly; and positive regulation of T-helper 17 cell lineage commitment. Predicted to act upstream of or within neural tube closure. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2).
RGD Description
Predicted to enable chromatin binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin looping; nucleosome assembly; and positive regulation of T-helper 17 cell lineage commitment. Predicted to act upstream of or within neural tube closure. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22880
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
4.728M4.729M4.730M4.731M4.732M4.733M4.734M4.735M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions