Version: 8.1.0
Date: Fri Apr 18 2025
Atg14
Rattus norvegicusRGD:1304610
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Atg14

Species
Rattus norvegicus
Symbol
Atg14
Name
autophagy related 14
Synonyms
  • ATG14 autophagy related 14 homolog
  • ATG14 autophagy related 14 homolog (S. cerevisiae)
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Predicted to be involved in several processes, including early endosome to late endosome transport; macroautophagy; and regulation of protein phosphorylation. Predicted to act upstream of or within defense response to other organism; endosome to lysosome transport; and regulation of triglyceride metabolic process. Predicted to be located in several cellular components, including mitochondria-associated endoplasmic reticulum membrane contact site; phagocytic vesicle; and phagophore assembly site membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class III. Predicted to be active in autophagosome and phagophore assembly site. Predicted to be extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Orthologous to human ATG14 (autophagy related 14).
RGD Description
Predicted to enable GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Predicted to be involved in several processes, including early endosome to late endosome transport; macroautophagy; and regulation of protein phosphorylation. Predicted to act upstream of or within defense response to other organism; endosome to lysosome transport; and regulation of triglyceride metabolic process. Predicted to be located in several cellular components, including mitochondria-associated endoplasmic reticulum membrane contact site; phagocytic vesicle; and phagophore assembly site membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class III. Predicted to be active in autophagosome and phagophore assembly site. Predicted to be extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Orthologous to human ATG14 (autophagy related 14); PARTICIPATES IN autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13664
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Atg14 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Atg14 role
            Atg14 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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