Enables ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Predicted to be located in condensed chromosome and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
RGD Description
Enables ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Predicted to be located in condensed chromosome and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.