Gene

Dis3

Species
Rattus norvegicus
Symbol
Dis3
Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms
  • DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
  • DIS3 mitotic control
Biotype
protein coding gene
Automated Description
Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease).
RGD Description
Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease); PARTICIPATES IN ribosome biogenesis pathway; RNA degradation pathway; INTERACTS WITH methamphetamine; paracetamol; tetrachloromethane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23355
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
75.825M75.830M75.835M75.840M75.845M75.850M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions