Gene

Lrp6

Species
Rattus norvegicus
Symbol
Lrp6
Name
LDL receptor related protein 6
Synonyms
  • LOC312781
  • low density lipoprotein receptor-related protein 6
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including Wnt-protein binding activity; coreceptor activity; and frizzled binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to peptide hormone. Located in neuronal cell body. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6).
RGD Description
Predicted to enable several functions, including Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to peptide hormone. Located in neuronal cell body. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46513
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensLRP610 of 10YesYes  
Mus musculusLrp69 of 9YesYes   
Xenopus tropicalislrp65 of 9YesYes   
Danio reriolrp63 of 9YesYes   
Drosophila melanogasterarr7 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Lrp51161782697 of 9 
Lrp42125062453 of 9 
Lrp13148953343 of 9 
Lrp24144151332 of 9 
Egf580643262 of 9 
Lrp8642252353 of 9 
Vldlr739554343 of 9 
Ldlr840850333 of 9 
Lrp12946535252 of 9 
Lrp31040134252 of 9 
Lrp101138934252 of 9 
Nid21222260412 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
167.28M167.30M167.32M167.34M167.36M167.38M167.40M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051339.1:g.167277861G>Avariant
SNP
  • intron variant
NC_051339.1:g.167281462C>Tvariant
SNP
  • intron variant
NC_051339.1:g.167296789T>Cvariant
NC_051339.1:g.167318498G>Avariant
NC_051339.1:g.167329677A>Gvariant
SNP
  • intron variant
NC_051339.1:g.167361576A>Gvariant
NC_051339.1:g.167362513C>Tvariant
SNP
  • intron variant
NC_051339.1:g.167367225C>Tvariant
SNP
  • intron variant
NC_051339.1:g.167377642T>Cvariant
SNP
  • intron variant
NC_051339.1:g.167278648A>Gvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
167.28M167.30M167.32M167.34M167.36M167.38M167.40MENSRNOT00000082102.2 (Lrp6)NM_001107892.1 (Lrp6)NM_001401820.1 (Lrp6)XM_039107695.2 (Lrp6)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

Lrp6 role
Lrp6 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
Wnt3aRattus norvegicus
suppressed gene
phenotypic suppression (sensu BioGRID)
  • abnormal protein level, partial rescue
PMID:15143170
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