Gene

Hcls1

Species
Rattus norvegicus
Symbol
Hcls1
Name
hematopoietic cell specific Lyn substrate 1
Synonyms
  • hematopoietic lineage cell-specific protein
  • LOC102552892
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in cortical actin cytoskeleton; plasma membrane; and site of polarized growth. Predicted to colocalize with actin filament. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1).
RGD Description
Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in cortical actin cytoskeleton; plasma membrane; and site of polarized growth. Predicted to colocalize with actin filament. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10829
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
63.818M63.820M63.822M63.824M63.826M63.828M63.830M63.832M63.834M63.836M63.838M63.840M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions