Version: 8.0.0
Date: Tue Jan 28 2025
Ppp2r1b
Rattus norvegicusRGD:1304764
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppp2r1b

Species
Rattus norvegicus
Symbol
Ppp2r1b
Name
protein phosphatase 2 scaffold subunit A beta
Synonyms
  • LOC315648
  • PP2A subunit A isoform PR65-beta
Biotype
protein coding gene
Automated Description
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in several processes, including meiotic sister chromatid cohesion, centromeric; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and spindle assembly. Predicted to be located in membrane raft. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta).
RGD Description
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in apoptotic process involved in morphogenesis; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Predicted to be located in membrane raft. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; Chagas disease pathway; hepatitis C pathway; INTERACTS WITH 1,3-dinitrobenzene; 6-propyl-2-thiouracil; amitrole.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10648
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ppp2r1b molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ppp2r1b role
            Ppp2r1b genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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