Version: 8.0.0
Date: Tue Jan 28 2025
Atg7
Rattus norvegicusRGD:1304817
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Atg7

Species
Rattus norvegicus
Symbol
Atg7
Name
autophagy related 7
Synonyms
  • APG7-like
  • Apg7l
Biotype
protein coding gene
Automated Description
Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of programmed cell death; and positive regulation of macroautophagy. Located in axon. Used to study cardiac arrest; degenerative disc disease; and high grade glioma. Biomarker of artery disease (multiple); diabetic retinopathy; metabolic dysfunction-associated steatohepatitis; neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7).
RGD Description
Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; cellular response to sodium arsenite; and negative regulation of mitochondrial DNA replication. Located in axon. Used to study high grade glioma. Biomarker of hypertension; myocardial infarction; neurodegenerative disease; non-alcoholic fatty liver; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-methoxyethanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10953
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Atg7 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Atg7 role
            Atg7 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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