Version: 8.0.0
Date: Tue Jan 28 2025
Cldn19
Rattus norvegicusRGD:1305000
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cldn19

Species
Rattus norvegicus
Symbol
Cldn19
Name
claudin 19
Synonyms
  • claudin-19
  • LOC298487
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; paracellular transport; and regulation of macromolecule metabolic process. Predicted to act upstream of or within apical junction assembly; neuronal action potential propagation; and tight junction organization. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and mesaxon. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 5 with ocular involvement. Orthologous to human CLDN19 (claudin 19).
RGD Description
Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; paracellular transport; and regulation of gene expression. Predicted to act upstream of or within apical junction assembly; neuronal action potential propagation; and tight junction organization. Predicted to be located in several cellular components, including apical junction complex; basolateral plasma membrane; and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 5 with ocular involvement. Orthologous to human CLDN19 (claudin 19); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12002
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cldn19 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Cldn19 role
            Cldn19 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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