Version: 8.1.0
Date: Fri Apr 18 2025
Baz2a
Rattus norvegicusRGD:1305037
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Baz2a

Species
Rattus norvegicus
Symbol
Baz2a
Name
bromodomain adjacent to zinc finger domain, 2A
Synonyms
  • bromodomain adjacent to zinc finger domain protein 2A
  • LOC304601
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including DNA binding activity; chromatin-protein adaptor activity; and lysine-acetylated histone binding activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase I. Predicted to act upstream of or within rDNA heterochromatin formation. Predicted to be located in cytosol; nuclear speck; and nucleolus. Predicted to be part of NoRC complex and chromatin silencing complex. Predicted to be active in rDNA heterochromatin. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A).
RGD Description
Predicted to enable several functions, including DNA binding activity; chromatin-protein adaptor activity; and lysine-acetylated histone binding activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase I. Predicted to act upstream of or within rDNA heterochromatin formation. Predicted to be located in cytosol; nuclear speck; and nucleolus. Predicted to be part of NoRC complex and chromatin silencing complex. Predicted to be active in rDNA heterochromatin. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A); INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; amphetamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45915
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Baz2a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Baz2a role
            Baz2a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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