Species

Rattus norvegicus

Symbol

Slc30a10

Name

solute carrier family 30, member 10

Synonyms

calcium/manganese antiporter SLC30A10
LOC289353

Biotype

protein coding gene

Automated Description

Predicted to enable calcium:manganese antiporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including detoxification of zinc ion; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endosome membrane; and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10).

RGD Description

Predicted to enable calcium:manganese antiporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including detoxification of zinc ion; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endosome membrane; and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR45820

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr13:96998143...97048076 + (49.93 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Slc30a10 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Slc30a10 role	Slc30a10 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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