Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within in utero embryonic development and mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit).
RGD Description
Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within in utero embryonic development and mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.