Gene

Polg2

Species
Rattus norvegicus
Symbol
Polg2
Name
DNA polymerase gamma 2, accessory subunit
Synonyms
  • DNA polymerase subunit gamma-2, mitochondrial
  • LOC303612
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within in utero embryonic development and mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit).
RGD Description
Predicted to enable several functions, including DNA polymerase binding activity; DNA polymerase processivity factor activity; and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication and positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within in utero embryonic development and mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 16; and mitochondrial DNA depletion syndrome 16B. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10745
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
91.713M91.714M91.715M91.716M91.717M91.718M91.719M91.720M91.721M91.722M91.723M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions