Version: 8.0.0
Date: Tue Jan 28 2025
Kmt5c
Rattus norvegicusRGD:1305226
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kmt5c

Species
Rattus norvegicus
Symbol
Kmt5c
Name
lysine methyltransferase 5C
Synonyms
  • [histone H4]-lysine20 N-methyltransferase KMT5B
  • [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; histone H4K20 methyltransferase activity; and histone binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in condensed chromosome, centromeric region; nucleoplasm; and pericentric heterochromatin. Predicted to be active in nucleus. Biomarker of liver benign neoplasm. Orthologous to human KMT5C (lysine methyltransferase 5C).
RGD Description
Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; histone H4K20 methyltransferase activity; and histone binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to act upstream of or within chromatin remodeling. Predicted to be located in condensed chromosome, centromeric region; nucleoplasm; and pericentric heterochromatin. Predicted to be active in nucleus. Biomarker of liver benign neoplasm. Orthologous to human KMT5C (lysine methyltransferase 5C); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12977
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kmt5c molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Kmt5c role
            Kmt5c genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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