Gene

Ror2

Species
Rattus norvegicus
Symbol
Ror2
Name
receptor tyrosine kinase-like orphan receptor 2
Synonyms
  • LOC306782
  • tyrosine-protein kinase transmembrane receptor ROR2
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of macrophage differentiation; positive regulation of protein serine/threonine kinase activity; and regulation of synaptic signaling by nitric oxide. Located in several cellular components, including cell surface; microtubule; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2).
RGD Description
Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of macrophage differentiation; positive regulation of protein serine/threonine kinase activity; and regulation of synaptic signaling by nitric oxide. Located in several cellular components, including cell surface; microtubule; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; atrazine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
11.98M12.00M12.02M12.04M12.06M12.08M12.10M12.12M12.14M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions