Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of macrophage differentiation; positive regulation of protein serine/threonine kinase activity; and regulation of synaptic signaling by nitric oxide. Located in several cellular components, including cell surface; microtubule; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2).
RGD Description
Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of macrophage differentiation; positive regulation of protein serine/threonine kinase activity; and regulation of synaptic signaling by nitric oxide. Located in several cellular components, including cell surface; microtubule; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; atrazine.