Gene

Ltf

Species
Rattus norvegicus
Symbol
Ltf
Name
lactotransferrin
Synonyms
  • lactoferrin
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to be located in cell surface and specific granule. Predicted to be part of protein-containing complex. Predicted to be active in endosome; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin).
RGD Description
Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of cell population proliferation; and regulation of signal transduction. Predicted to be located in cell surface and specific granule. Predicted to be part of protein-containing complex. Predicted to be active in endosome; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin); INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; apigenin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11485
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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111.000M111.002M111.004M111.006M111.008M111.010M111.012M111.014M111.016M111.018M111.020M111.022M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions