Gene

Mcm2

Species
Rattus norvegicus
Symbol
Mcm2
Name
minichromosome maintenance complex component 2
Synonyms
  • DNA replication licensing factor MCM2
  • LOC312538
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity; enzyme binding activity; and histone binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process; apoptotic process; and cochlea development. Predicted to act upstream of or within cellular response to interleukin-4 and nucleosome assembly. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of CMG complex; MCM complex; and nuclear origin of replication recognition complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2).
RGD Description
Predicted to enable DNA binding activity; enzyme binding activity; and histone binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process; apoptotic process; and cochlea development. Predicted to act upstream of or within cellular response to interleukin-4 and nucleosome assembly. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of CMG complex; MCM complex; and nuclear origin of replication recognition complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11630
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
121.348M121.350M121.352M121.354M121.356M121.358M121.360M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions