Version: 8.1.0Date: Fri Apr 18 2025
Gene
Pfdn1
- Species
- Rattus norvegicus
- Symbol
- Pfdn1
- Name
- prefoldin subunit 1
- Synonyms
- LOC361310
- prefoldin 1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1).
- RGD Description
- Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR20903
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | PFDN1 | 9 of 10 | Yes | Yes | ☑☑☑☑☐☑☑☑☑☑ |
| Mus musculus | Pfdn1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Xenopus tropicalis | pfdn1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Danio rerio | pfdn1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Drosophila melanogaster | Pfdn1 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Caenorhabditis elegans | pfd-1 | 5 of 9 | Yes | Yes | ☑ ☑☑☐☑☐☑☐☐ |
| Saccharomyces cerevisiae S288C | PFD1 | 3 of 9 | Yes | Yes | ☐ ☑☐☐☑☐☑☐☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr18:28014145...28067148 - (53.00 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_051353.1:g.28064330T>C | variant | SNP
| |||||
| NC_051353.1:g.28065748C>A | variant | SNP
| |||||
| NC_051353.1:g.28022592T>A | variant | SNP
| |||||
| NC_051353.1:g.28027946C>T | variant | SNP
| |||||
| NC_051353.1:g.28063128G>C | variant | SNP
| |||||
| NC_051353.1:g.28043975T>C | variant | SNP
| |||||
| NC_051353.1:g.28041594T>A | variant | SNP
| |||||
| NC_051353.1:g.28046085T>C | variant | SNP
| |||||
| NC_051353.1:g.28051354A>G | variant | SNP
| |||||
| NC_051353.1:g.28052385A>G | variant | SNP
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Sequence Feature Viewer
- Genome location
- Chr18:28014145...28067148 - (53.00 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction