Gene

Cadm2

Species
Rattus norvegicus
Symbol
Cadm2
Name
cell adhesion molecule 2
Synonyms
  • Igsf4d
  • immunoglobulin superfamily member 4D
Biotype
protein coding gene
Automated Description
Involved in synaptic membrane adhesion. Located in axon and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2).
RGD Description
Involved in synaptic membrane adhesion. Located in axon and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45889
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCADM210 of 10YesYes  
Mus musculusCadm29 of 9YesYes   
Xenopus tropicaliscadm28 of 9YesYes   
Danio reriocadm2b9 of 9YesYes   
Danio reriocadm2a8 of 9NoYes   
Drosophila melanogasterdpr162 of 9YesYes   
Drosophila melanogasterdpr192 of 9YesYes   
Drosophila melanogasterdpr152 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cadm1145261445 of 9 
Cadm3242164485 of 9 
Cadm4342952354 of 9 
Nectin3443243242 of 9 
Pvr541340262 of 9 
Nectin2641039262 of 9 
Nectin4742738242 of 9 
Nectin1836137252 of 9 
Cd200l2938634202 of 9 
Crtam1026844272 of 9 
Cd200l11135431202 of 9 
Cd2001222838222 of 9 
Smagp1311748362 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
4.6M4.7M4.8M4.9M5.0M5.1M5.2M5.3M5.4M5.5M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Cadm2Tn(sb-T2/Bart3)2.180Mcwi
  • Cadm2Tn(sb-T2/Bart3)2.180Mcwi
  • Igsf4dTn(sb-T2/Bart3)2.180Mcwi
allele
NC_051346.1:g.4714688C>Gvariant
SNP
  • intron variant
NC_051346.1:g.4720861G>Avariant
SNP
  • intron variant
NC_051346.1:g.4728391G>Avariant
SNP
  • intron variant
NC_051346.1:g.4742114C>Tvariant
SNP
  • intron variant
NC_051346.1:g.4742223T>Cvariant
SNP
  • intron variant
NC_051346.1:g.4845790G>Tvariant
SNP
  • intron variant
NC_051346.1:g.4882845G>Avariant
SNP
  • intron variant
NC_051346.1:g.4889051T>Cvariant
SNP
  • intron variant
NC_051346.1:g.4891114A>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 2,454 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
F344-Cadm2Tn(sb-T2/Bart3)2.180McwiRGD
Showing 1 - 1 of 1 rows
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Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
4.6M4.7M4.8M4.9M5.0M5.1M5.2M5.3M5.4M5.5MENSRNOT00000046370.6 (Cadm2)ENSRNOT00000087133.2 (Cadm2)ENSRNOT00000095471.1 (Cadm2)ENSRNOT00000099827.1 (Cadm2)ENSRNOT00000108768.1 (Cadm2)ENSRNOT00000111554.1 (Cadm2)ENSRNOT00000115818.1 (Cadm2)NM_001047102.2 (Cadm2)XM_039088451.2 (Cadm2)XM_039088453.2 (Cadm2)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Cadm2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
UbcRattus norvegicus
protein
  • affinity chromatography technology
PMID:22871113
Showing 1 - 1 of 1 rows
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Genetic Interactions

No data available