Version: 8.0.0
Date: Tue Jan 28 2025
Casp8ap2
Rattus norvegicusRGD:1305771
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Casp8ap2

Species
Rattus norvegicus
Symbol
Casp8ap2
Name
caspase 8 associated protein 2
Synonyms
  • CASP8-associated protein 2
  • LOC313128
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including SUMO polymer binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and identical protein binding activity. Predicted to be involved in cell surface receptor signaling pathway; cellular response to mechanical stimulus; and positive regulation of cysteine-type endopeptidase activity. Located in cytoplasm and nucleus. Orthologous to human CASP8AP2 (caspase 8 associated protein 2).
RGD Description
Predicted to enable several functions, including SUMO polymer binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and identical protein binding activity. Predicted to be involved in Fas signaling pathway; cellular response to mechanical stimulus; and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytoplasm and nucleus. Orthologous to human CASP8AP2 (caspase 8 associated protein 2); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15489
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Casp8ap2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Casp8ap2 role
            Casp8ap2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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