Gene

Dsp

Species
Rattus norvegicus
Symbol
Dsp
Name
desmoplakin
Synonyms
  • DP
  • LOC306871
Biotype
protein coding gene
Automated Description
Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin).
RGD Description
Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23169
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensDSP10 of 10YesYes  
Mus musculusDsp9 of 9YesYes   
Xenopus tropicalisdsp9 of 9YesYes   
Danio reriodspb6 of 9YesYes   
Danio reriodspa6 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Plec1420342273 of 9 
Dst2332136223 of 9 
Macf13311939222 of 9 
Sptan14290835182 of 9 
Sptbn15244736192 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051352.1:g.26629604A>Tvariant
SNP
  • synonymous variant
NC_051352.1:g.26631971C>Tvariant
SNP
  • intron variant
NC_051352.1:g.26632592G>Tvariant
SNP
  • intron variant
NC_051352.1:g.26632604G>Tvariant
SNP
  • intron variant
NC_051352.1:g.26633516G>Tvariant
SNP
  • intron variant
NC_051352.1:g.26655842A>Gvariant
SNP
  • intron variant
NC_051352.1:g.26647030G>Avariant
SNP
  • intron variant
NC_051352.1:g.26649010C>Tvariant
SNP
  • intron variant
NC_051352.1:g.26623801G>Avariant
SNP
  • 3 prime UTR variant
NC_051352.1:g.26634918G>Avariant
SNP
  • intron variant
Showing 1 - 10 of 188 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
26.625M26.630M26.635M26.640M26.645M26.650M26.655M26.660M26.665M26.670M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Dsp molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ABCG1Homo sapiens
protein
  • affinity chromatography technology
PMID:26296893
protein
DaoRattus norvegicus
protein
  • affinity chromatography technology
PMID:21700703
protein
RNF207Homo sapiens
protein
  • affinity chromatography technology
PMID:35352799
Showing 1 - 3 of 3 rows
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Genetic Interactions

No data available