Gene

Sirt7

Species
Rattus norvegicus
Symbol
Sirt7
Name
sirtuin 7
Synonyms
  • LOC303745
  • NAD-dependent deacetylase sirtuin-7
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including NAD+ binding activity; NAD-dependent protein lysine deacylase activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including chromatin remodeling; protein deacylation; and regulation of macromolecule metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (sirtuin 7).
RGD Description
Predicted to enable several functions, including chromatin binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and protein-propionyllysine depropionylase activity. Predicted to be involved in several processes, including chromatin remodeling; protein deacylation; and regulation of gene expression. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (sirtuin 7); PARTICIPATES IN histone modification pathway; RNA polymerase I transcription pathway; Sirtuin mediated pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11085
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
105.897M105.898M105.899M105.900M105.901M105.902M105.903M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions