Version: 8.0.0Date: Tue Jan 28 2025
Gene
Cc2d1a
- Species
- Rattus norvegicus
- Symbol
- Cc2d1a
- Name
- coiled-coil and C2 domain containing 1A
- Synonyms
- coiled-coil and C2 domain-containing protein 1A
- five prime repressor element under dual repression-binding protein 1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of snRNA transcription by RNA polymerase II; positive regulation of canonical NF-kappaB signal transduction; and regulation of postsynapse assembly. Predicted to act upstream of or within several processes, including apical dendrite arborization; negative regulation of transcription by RNA polymerase II; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 3 and intellectual disability. Orthologous to human CC2D1A (coiled-coil and C2 domain containing 1A).
- RGD Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of snRNA transcription by RNA polymerase II; positive regulation of canonical NF-kappaB signal transduction; and regulation of postsynapse assembly. Predicted to act upstream of or within several processes, including apical dendrite arborization; negative regulation of transcription by RNA polymerase II; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 3 and intellectual disability. Orthologous to human CC2D1A (coiled-coil and C2 domain containing 1A); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; allethrin.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13076
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:24011897...24026937 + (15.04 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.