Gene

Mettl23

Species
Rattus norvegicus
Symbol
Mettl23
Name
methyltransferase 23, arginine
Synonyms
  • histone-arginine methyltransferase METTL23
  • hypothetical protein LOC287918
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor binding activity; heat shock protein binding activity; and histone H3R17 methyltransferase activity. Predicted to be involved in cognition; epigenetic programming in the zygotic pronuclei; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of with a positive effect on epigenetic programing of male pronucleus. Predicted to be located in female pronucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and male pronucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine).
RGD Description
Predicted to enable DNA-binding transcription factor binding activity; heat shock protein binding activity; and histone H3R17 methyltransferase activity. Predicted to be involved in cognition; epigenetic programming in the zygotic pronuclei; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of with a positive effect on epigenetic programing of male pronucleus. Predicted to be located in female pronucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and male pronucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14614
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            102.048M102.049M102.050M102.051M102.052M102.053M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Mettl23 molecule type
            Interactor gene
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              Genetic Interactions

              Mettl23 role
              Mettl23 genetic perturbation
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