Gene

Pik3cg

Species
Rattus norvegicus
Symbol
Pik3cg
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Synonyms
  • phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Biotype
protein coding gene
Automated Description
Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
RGD Description
Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-nonylphenol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
48.770M48.775M48.780M48.785M48.790M48.795M48.800M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions