Gene

Fras1

Species
Rattus norvegicus
Symbol
Fras1
Name
Fraser extracellular matrix complex subunit 1
Synonyms
  • extracellular matrix organizing protein FRAS1
  • extracellular matrix protein FRAS1
Biotype
protein coding gene
Automated Description
Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
RGD Description
Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45739
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFRAS110 of 10YesYes  
Mus musculusFras19 of 9YesYes   
Xenopus tropicalisfras13 of 9YesYes   
Danio reriofras18 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Frem21295649323 of 9 
Frem32210943283 of 9 
Frem13201341263 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Fras1 (Rno)
FRAS1 (Hsa)
Fras1 (Mmu)
fras1 (Xtr)
fras1 (Dre)
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensFRAS1
is implicated inFraser syndrome 1
  • IAGP
    Mus musculusFras1
    is implicated inclubfoot
    • TAS
      Mus musculusFras1
      is implicated inFraser syndrome
      • TAS
        Showing 1 - 3 of 3 rows
        per page

        Alleles and Variants

        No mapped variant information available
        Allele/Variant Symbol
        Allele Synonyms
        Category
        Variant
        Variant type
        Molecular consequence
        Has Disease Annotations
        Has Phenotype Annotations
        NC_051349.1:g.13077461G>Avariant
        SNP
        • intron variant
        NC_051349.1:g.13077547G>Avariant
        SNP
        • intron variant
        NC_051349.1:g.13090172T>Cvariant
        SNP
        • intron variant
        NC_051349.1:g.13075540A>Cvariant
        SNP
        • intron variant
        NC_051349.1:g.13101732T>Cvariant
        SNP
        • intron variant
        NC_051349.1:g.13107616C>Gvariant
        SNP
        • intron variant
        NC_051349.1:g.13128049C>Avariant
        SNP
        • intron variant
        NC_051349.1:g.13128393A>Gvariant
        SNP
        • intron variant
        NC_051349.1:g.13110953A>Gvariant
        SNP
        • intron variant
        NC_051349.1:g.13111353T>Cvariant
        SNP
        • intron variant
        Showing 1 - 10 of 3,082 rows
        per page

        Transgenic Alleles

        No data available

        Models

        No data available

        Sequence Feature Viewer

        Genome location
        Assembly version
        mRatBN7.2
        Viewer Help
        12.80M12.85M12.90M12.95M13.00M13.05M13.10M13.15M13.20M

        Sequence Details

        Transcript: Mode:
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        Expression

        Primary Sources
        None
        Other Sources
        Must provide at least one subject
        Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

        Molecular Interactions

        No data available

        Genetic Interactions

        No data available