Version: 8.0.0
Date: Tue Jan 28 2025
Kpna6
Rattus norvegicusRGD:1306570
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kpna6

Species
Rattus norvegicus
Symbol
Kpna6
Name
karyopherin subunit alpha 6
Synonyms
  • importin
  • importin subunit alpha-7
Biotype
protein coding gene
Automated Description
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytoplasm and host cell. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6).
RGD Description
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytoplasm and host cell. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23316
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensKPNA610 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusKpna69 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicaliskpna64 of 9YesYes☑ ☐☐☑☑☐☑☐☐  
Danio reriokpna69 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterKap-α19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeSRP19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Kpna1153890817 of 9☑☐☑☐☑☑☑☑☑ 
Kpna5153889827 of 9☑☐☑☐☑☑☑☑☑ 
Kpna4253266484 of 9☑☐☐☐☑☐☑☑☐ 
Kpna2352465484 of 9☑☐☐☐☑☐☑☑☐ 
Kpna3449467494 of 9☑☐☐☐☑☐☑☑☐ 
Kpna7551260394 of 9☑☐☐☐☑☐☑☑☐ 
Kpna2l164 of 9☑☐☐☐☑☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051340.1:g.141999428C>Tvariant
    SNP
    • intron variant
    NC_051340.1:g.141999707G>Avariant
    NC_051340.1:g.141999731T>Avariant
    NC_051340.1:g.142008289G>Tvariant
    NC_051340.1:g.142010583C>Tvariant
    SNP
    • intron variant
    NC_051340.1:g.142014435G>Avariant
    NC_051340.1:g.142011327G>Avariant
    SNP
    • intron variant
    NC_051340.1:g.142017383G>Avariant
    SNP
    • intron variant
    NC_051340.1:g.142019607T>Cvariant
    SNP
    • intron variant
    NC_051340.1:g.141996306G>Avariant
    SNP
    • intron variant
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available