Gene

Clic2

Species
Rattus norvegicus
Symbol
Clic2
Name
chloride intracellular channel 2
Synonyms
  • chloride intracellular channel protein 2
  • glutaredoxin-like oxidoreductase CLIC2
Biotype
protein coding gene
Automated Description
Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; negative regulation of ryanodine-sensitive calcium-release channel activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC2 (chloride intracellular channel 2).
RGD Description
Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; negative regulation of ryanodine-sensitive calcium-release channel activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC2 (chloride intracellular channel 2); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,7-dihydropurine-6-thione.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45476
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions