Version: 8.0.0
Date: Tue Jan 28 2025
Clic2
Rattus norvegicusRGD:1306580
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Clic2

Species
Rattus norvegicus
Symbol
Clic2
Name
chloride intracellular channel 2
Synonyms
  • chloride intracellular channel protein 2
  • glutaredoxin-like oxidoreductase CLIC2
Biotype
protein coding gene
Automated Description
Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; negative regulation of ryanodine-sensitive calcium-release channel activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC2 (chloride intracellular channel 2).
RGD Description
Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; negative regulation of ryanodine-sensitive calcium-release channel activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC2 (chloride intracellular channel 2); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,7-dihydropurine-6-thione.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45476
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Clic2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Clic2 role
            Clic2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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