Gene

Mthfs

Species
Rattus norvegicus
Symbol
Mthfs
Name
methenyltetrahydrofolate synthetase
Synonyms
  • 5-formyltetrahydrofolate cyclo-ligase
  • 5, 10-methenyltetrahydrofolate synthetase
Biotype
protein coding gene
Automated Description
Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid catabolic process; glutamate metabolic process; and tetrahydrofolate interconversion. Predicted to be located in cytosol and mitochondrial matrix. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase).
RGD Description
Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in dicarboxylic acid metabolic process; folic acid-containing compound biosynthetic process; and tetrahydrofolate interconversion. Predicted to be located in cytosol and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23407
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
89.73M89.74M89.75M89.76M89.77M89.78M89.79M89.80M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions