Version: 8.1.0Date: Fri Apr 18 2025
Gene
Epha2
- Species
- Rattus norvegicus
- Symbol
- Epha2
- Name
- Eph receptor A2
- Synonyms
- ephrin receptor EphA2
- ephrin type-A receptor 2
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including epithelial cell differentiation; mammary gland epithelium development; and regulation of cell migration. Predicted to act upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Predicted to be located in several cellular components, including focal adhesion; lamellipodium; and tight junction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2).
- RGD Description
- Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including epithelial cell differentiation; mammary gland epithelium development; and regulation of cell migration. Predicted to act upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Predicted to be located in several cellular components, including focal adhesion; lamellipodium; and tight junction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46877
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr5:153605644...153634117 + (28.47 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.