Version: 8.0.0
Date: Tue Jan 28 2025
Lama1
Rattus norvegicusRGD:1307207
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Lama1

Species
Rattus norvegicus
Symbol
Lama1
Name
laminin subunit alpha 1
Synonyms
  • laminin subunit alpha-1
  • laminin-1
Biotype
protein coding gene
Automated Description
Predicted to enable glycosphingolipid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including axon guidance; blood vessel morphogenesis; and protein phosphorylation. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Predicted to be located in several cellular components, including cell-cell junction; extracellular matrix; and extracellular space. Predicted to be part of laminin-1 complex and laminin-3 complex. Predicted to be active in basement membrane. Orthologous to human LAMA1 (laminin subunit alpha 1).
RGD Description
Predicted to enable glycosphingolipid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including axon guidance; blood vessel morphogenesis; and protein phosphorylation. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Predicted to be located in several cellular components, including cell-cell junction; extracellular matrix; and extracellular space. Predicted to be part of laminin-1 complex and laminin-3 complex. Predicted to be active in basement membrane. Orthologous to human LAMA1 (laminin subunit alpha 1); PARTICIPATES IN glypican signaling pathway; syndecan signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10574
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Lama1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Lama1 role
            Lama1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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