Version: 8.0.0Date: Tue Jan 28 2025
Gene
Ccdc88c
- Species
- Rattus norvegicus
- Symbol
- Ccdc88c
- Name
- coiled-coil domain containing 88C
- Synonyms
- LOC362770
- RGD1307429
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including G-protein alpha-subunit binding activity; PDZ domain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in several processes, including apical constriction; negative regulation of canonical Wnt signaling pathway; and protein destabilization. Predicted to act upstream of or within with a positive effect on positive regulation of JNK cascade. Predicted to act upstream of or within several processes, including mucociliary clearance; negative regulation of microtubule depolymerization; and respiratory basal cell differentiation. Predicted to be located in cell junction. Predicted to be active in apical junction complex; centrosome; and cytoplasm. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to human CCDC88C (coiled-coil domain containing 88C).
- RGD Description
- Predicted to enable several functions, including G-protein alpha-subunit binding activity; PDZ domain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in several processes, including apical constriction; negative regulation of canonical Wnt signaling pathway; and protein destabilization. Predicted to act upstream of or within with a positive effect on positive regulation of JNK cascade. Predicted to act upstream of or within several processes, including mucociliary clearance; negative regulation of microtubule depolymerization; and respiratory basal cell differentiation. Predicted to be located in cell junction. Predicted to be active in apical junction complex; centrosome; and cytoplasm. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to human CCDC88C (coiled-coil domain containing 88C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; atrazine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR18947
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr6:120169738...120289555 - (119.82 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.