Species

Rattus norvegicus

Symbol

Tiam1

Name

TIAM Rac1 associated GEF 1

Synonyms

rho guanine nucleotide exchange factor TIAM1
T-cell lymphoma invasion and metastasis 1

Biotype

protein coding gene

Automated Description

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1).

RGD Description

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR46001

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr11:29031347...29380153 - (348.81 kb)

Assembly version

mRatBN7.2

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Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Tiam1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Tiam1 role	Tiam1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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