Gene

Sesn1

Species
Rattus norvegicus
Symbol
Sesn1
Name
sestrin 1
Synonyms
  • LOC294518
  • sestrin-1
Biotype
protein coding gene
Automated Description
Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1).
RGD Description
Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12474
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSESN19 of 10YesYes  
Mus musculusSesn19 of 9YesYes   
Xenopus tropicalissesn18 of 9YesYes   
Danio reriosesn19 of 9YesYes   
Drosophila melanogasterSesn9 of 9YesYes   
Caenorhabditis eleganssesn-19 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Sesn3147078627 of 9 
Sesn2246172597 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
45.30M45.31M45.32M45.33M45.34M45.35M45.36M45.37M45.38M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051355.1:g.45295614T>Cvariant
SNP
  • 5 prime UTR variant
NC_051355.1:g.45373670G>Tvariant
SNP
  • intron variant
NC_051355.1:g.45379337A>Tvariant
SNP
  • intron variant
NC_051355.1:g.45332842A>Gvariant
SNP
  • intron variant
NC_051355.1:g.45336336C>Tvariant
SNP
  • intron variant
NC_051355.1:g.45343736G>Tvariant
SNP
  • intron variant
NC_051355.1:g.45345210C>Avariant
SNP
  • intron variant
NC_051355.1:g.45321419G>Avariant
SNP
  • intron variant
NC_051355.1:g.45299247A>Gvariant
SNP
  • intron variant
NC_051355.1:g.45299259T>Avariant
SNP
  • intron variant
Showing 1 - 10 of 427 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
45.30M45.31M45.32M45.33M45.34M45.35M45.36M45.37M45.38MENSRNOT00000065890.2 (Sesn1)ENSRNOT00000089611.2 (Sesn1)ENSRNOT00000116987.1 (Sesn1)NM_001414937.1 (Sesn1)XM_006256560.4 (Sesn1)ENSRNOT00000071045.3 (LOC499469)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available