Gene

Fech

Species
Rattus norvegicus
Symbol
Fech
Name
ferrochelatase
Synonyms
  • ferrochelatase, mitochondrial
  • LOC361338
Biotype
protein coding gene
Automated Description
Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase).
RGD Description
Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11108
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
57.950M57.955M57.960M57.965M57.970M57.975M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions