Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including actin filament; lamellipodium; and nuclear envelope. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2).
RGD Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase regulator activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including actin filament; lamellipodium; and nuclear envelope. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2); PARTICIPATES IN B cell receptor signaling pathway; ceramide signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.