Gene

Rac2

Species
Rattus norvegicus
Symbol
Rac2
Name
Rac family small GTPase 2
Synonyms
  • LOC366957
  • MGC105983
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including actin filament; lamellipodium; and nuclear envelope. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2).
RGD Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase regulator activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including actin filament; lamellipodium; and nuclear envelope. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2); PARTICIPATES IN B cell receptor signaling pathway; ceramide signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24072
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
110.105M110.110M110.115M110.120M110.125M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions