Gene

Fbxo4

Species
Rattus norvegicus
Symbol
Fbxo4
Name
F-box protein 4
Synonyms
  • F-box only protein 4
  • LOC310363
Biotype
protein coding gene
Automated Description
Predicted to enable protein homodimerization activity; ubiquitin protein ligase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macromolecule metabolic process; and protein polyubiquitination. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; protein destabilization; and regulation of DNA damage checkpoint. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO4 (F-box protein 4).
RGD Description
Predicted to enable protein homodimerization activity; ubiquitin protein ligase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macromolecule metabolic process; and telomere maintenance. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; protein destabilization; and regulation of DNA damage checkpoint. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO4 (F-box protein 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16008
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
53.176M53.178M53.180M53.182M53.184M53.186M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions