Gene

Fcho1

Species
Rattus norvegicus
Symbol
Fcho1
Name
FCH and mu domain containing endocytic adaptor 1
Synonyms
  • F-BAR domain only protein 1
  • FCH domain only 1
Biotype
protein coding gene
Automated Description
Predicted to enable AP-2 adaptor complex binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Is active in postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1).
RGD Description
Predicted to enable AP-2 adaptor complex binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Is active in postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23065
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensFCHO18 of 10YesYes  
Mus musculusFcho18 of 9YesYes   
Xenopus tropicalisfcho14 of 9YesYes   
Danio reriofcho13 of 9YesYes   
Drosophila melanogasterCG81764 of 9YesNo   
Caenorhabditis elegansfcho-16 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Fcho2191560425 of 9 
Sgip1283444315 of 9 
Pstpip2336342222 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
18.414M18.416M18.418M18.420M18.422M18.424M18.426M18.428M18.430M18.432M18.434M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051351.1:g.18431298T>Cvariant
SNP
  • intron variant
NC_051351.1:g.18434153G>Avariant
SNP
  • intron variant
NC_051351.1:g.18428772C>Tvariant
SNP
  • intron variant
NC_051351.1:g.18430174C>Tvariant
SNP
  • intron variant
NC_051351.1:g.18430170C>Gvariant
SNP
  • intron variant
NC_051351.1:g.18430204T>Gvariant
SNP
  • intron variant
NC_051351.1:g.18416793T>Cvariant
SNP
  • intron variant
NC_051351.1:g.18419349T>Cvariant
SNP
  • intron variant
NC_051351.1:g.18420475T>Cvariant
SNP
  • intron variant
NC_051351.1:g.18425634T>Cvariant
SNP
  • intron variant
Showing 1 - 10 of 72 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
18.414M18.416M18.418M18.420M18.422M18.424M18.426M18.428M18.430M18.432M18.434MENSRNOT00000040464.5 (Fcho1)ENSRNOT00000111337.1 (Fcho1)NM_001395712.1 (Fcho1)XM_006252864.5 (Fcho1)XM_006252865.5 (Fcho1)XM_008771083.4 (Fcho1)XM_017600027.3 (Fcho1)XM_039094302.2 (Fcho1)XM_039094304.2 (Fcho1)XM_039094305.2 (Fcho1)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available