Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of cardiac muscle cell proliferation; and positive regulation of cell cycle G1/S phase transition. Predicted to be located in chromatin. Predicted to be active in nucleus. Biomarker of acute kidney failure and acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); hypoparathyroidism; sensorineural hearing loss; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1).
RGD Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of cardiac muscle cell proliferation; and positive regulation of cell cycle G1/S phase transition. Predicted to be located in chromatin. Predicted to be active in nucleus. Biomarker of acute kidney failure and acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); hypoparathyroidism; sensorineural hearing loss; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; bisphenol A.