Gene

Tbx1

Species
Rattus norvegicus
Symbol
Tbx1
Name
T-box transcription factor 1
Synonyms
  • LOC360737
  • T-box 1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of cardiac muscle cell proliferation; and positive regulation of cell cycle G1/S phase transition. Predicted to be located in chromatin. Predicted to be active in nucleus. Biomarker of acute kidney failure and acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); hypoparathyroidism; sensorineural hearing loss; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1).
RGD Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of cardiac muscle cell proliferation; and positive regulation of cell cycle G1/S phase transition. Predicted to be located in chromatin. Predicted to be active in nucleus. Biomarker of acute kidney failure and acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); hypoparathyroidism; sensorineural hearing loss; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11267
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
82.410M82.411M82.412M82.413M82.414M82.415M82.416M82.417M82.418M82.419M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions