Gene

Ttc8

Species
Rattus norvegicus
Symbol
Ttc8
Name
tetratricopeptide repeat domain 8
Synonyms
  • LOC299246
  • tetratricopeptide repeat protein 8
Biotype
protein coding gene
Automated Description
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including centrosome; ciliary membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8).
RGD Description
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including centrosome; ciliary membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44177
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
118.200M118.205M118.210M118.215M118.220M118.225M118.230M118.235M118.240M118.245M118.250M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions