Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including centrosome; ciliary membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8).
RGD Description
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including centrosome; ciliary membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.